RECENT FEATURE ARTICLES

Improved techniques  and technology for cellular  and molecular pathology

Improved techniques and technology for cellular and molecular pathology

Contributors from Georgia, the UK, USA and Sweden made last year’s online Pathology 2016 event, organised by EuroSciCon, a truly international annual occasion.
A FIT approach: improving  sample integrity for faecal  haemoglobin testing

A FIT approach: improving sample integrity for faecal haemoglobin testing

Faecal immunochemical testing is the latest advance in the screening programme designed to identify patient with colorectal cancer, but success relies on the quality of the sample, as Matthew Davies explains.
Antibiotic prescribing targeted  with GAS test at Children’s Hospital

Antibiotic prescribing targeted with GAS test at Children’s Hospital

Antimicrobial resistance is a major problem in 21st-century medicine, the unwarranted treatment of infant pharyngitis being just one contributing factor. This has now been addressed using a lateral-flow immunochromatographic cassette test.
Acquire, learn, share, repeat:  an Innovation Academy update

Acquire, learn, share, repeat: an Innovation Academy update

Recent advances in technology and data science mean that there is more data about people, their habits and their health than ever before, but clinical utility cannot be fully realised without successful integration and analysis.
Point-of-care testing:  an expanding repertoire  in accident and emergency

Point-of-care testing: an expanding repertoire in accident and emergency

Patience Kapuya shares the results of a study of A&E clinician use of various POCT devices, comparability of results with the central laboratory, and the value of additional tests to speed decision-making in the emergency situation.
Reducing methicillin-resistant  Staphylococcus aureus  with chlorine dioxide

Reducing methicillin-resistant Staphylococcus aureus with chlorine dioxide

There is growing evidence to support the efficacy of disinfection with chlorine dioxide in the fight against healthcare-associated infections. One trust has achieved significant reductions in MRSA rates, resulting in major cost savings by implementing this disinfecting agent in its environmental cleaning process. Suzanne Callander and Louise Frampton report.
Measurand:  the first step to measurement uncertainty evaluation

Measurand: the first step to measurement uncertainty evaluation

In this first of a series of articles on individual aspects of the assessment of uncertainty of measurement, Stephen MacDonald begins with consideration of the measurand.
Clostridium difficile: value  of the GDH, toxin and tcdB testing algorithm

Clostridium difficile: value of the GDH, toxin and tcdB testing algorithm

Sarah Copsey-Mawer evaluates testing for glutamate dehydrogenase, toxin A/B and the tcdB gene, compared to the gold standards of toxigenic culture and cell cytotoxin neutralisation assay.
Current pathology in practice: a brief look in the literature

Current pathology in practice: a brief look in the literature

A small sample of research interest on Clostridium difficile infection, colorectal cancer and Mohs micrographic practice to be found in the current literature.
UN3373 sample packaging regulations: understanding your responsibilities

UN3373 sample packaging regulations: understanding your responsibilities

There are strict regulations governing how biological samples are packaged for mailing and it is vital that all staff understand the legislation and how to be fully compliant. If not, there could be serious consequences.
Support for the UK’s fastest service redesign to deliver modernisation efficiencies

Support for the UK’s fastest service redesign to deliver modernisation efficiencies

Through the rapid, smooth and seamless implementation of new automated equipment and systems, Beckman Coulter supported a South West London Pathology redesign across three large hospital sites. This article discusses how this was achieved and some of the efficiencies delivered.
Optimising workflow and patient treatment in the Mohs clinic in Cardiff

Optimising workflow and patient treatment in the Mohs clinic in Cardiff

Since 1992, the University Hospital of Wales, Cardiff, has been pioneering Mohs micrographic surgery, providing optimal patient care and rapid skin cancer treatment. Central to fast treatment time is cryosectioning, which, in Cardiff, is provided by the Thermo Scientific Cryostar NX70.
T helper 17 cells: roles in the pathogenesis of rheumatoid arthritis

T helper 17 cells: roles in the pathogenesis of rheumatoid arthritis

Functionally polarised CD4-positive T-cell responses based on their profile of cytokine secretion are seen in many chronic autoimmune inflammatory diseases. The focus in this review is the disease-triggering role of a T-helper subset of lymphocytes.
Testing for colorectal cancer: a focus on FIT technology

Testing for colorectal cancer: a focus on FIT technology

Quantitative faecal immunochemical testing looks set to reassure patients and clinicians concerned about colorectal cancer. Reducing referrals, colonoscopy investigations and overall waiting times, FIT enables GPs to manage patients confidently in primary care.
Microbiology transport systems: not all are created equal

Microbiology transport systems: not all are created equal

With the increasing trend towards centralisation of pathology services, it is important to consider carefully the type of swab and transport medium used when there is the potential for significant delay to sample processing.
Coeliac disease: from a refractory condition to fertility and cancer

Coeliac disease: from a refractory condition to fertility and cancer

The autoimmune coeliac disease results from ingestion of gluten in genetically predisposed individuals. The inflammatory damage caused to the mucosal lining of the small intestine gives rise to malabsorption and associated nutrient deficiency, and has been linked to a wide range of other medical conditions.
Viscosity-based detection: addressing HIL interference and sample integrity

Viscosity-based detection: addressing HIL interference and sample integrity

Interference due to haemolysis, icterus and lipaemia is a significant issue in automated coagulation testing, but technology from Stago now provides confidence in laboratory results in such cases.
Validation of the QUANTA Flash tTG  IgA detection system

Validation of the QUANTA Flash tTG IgA detection system

Femi Saleh and colleagues assess the value of a new chemiluminescence method to detect antibodies to human tissue transglutaminase in coeliac disease.
Capillary electrophoresis: technology and its uses

Capillary electrophoresis: technology and its uses

Capillary electrophoresis is an analytical technique that separates ions based on their electrophoretic mobility and has found laboratory application in the assessment of a number of clinical conditions, as Jean Deenmamode explains.
Automation: machines are finally taking over

Automation: machines are finally taking over

Mark Reed and Charlotte Duncan from Pro-Lab offer a brief insight into the changing world of laboratory testing, and focus on current antibiotic sensitivity testing.

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Latest Issue

Pathology In Practice

Pathology In Practice

Dec 2018

Molecular diagnostics and LAMP technology

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