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Intuitive in operation, the ultra-compact Guava PCA- 96 and Easycyte systems have set an international benchmark for single-cell analysis and counting in the 96-well format. Robot-scheduling software can control and integrate Guava PCA systems with all compatible robotic arms and liquid handling systems to deliver streamlined work flow. Using a series of user-defined worklists, the robot-scheduling software is able to send commands to the system while instructing the arm to move microplates to and from a Guava PCA system. This flexible work-list system allows the interchange and processing of different cell-based assays within a microplate series. GuavaLink enables the Guava PCA system to become a true walk-away, cell-based screening system, intelligently automating hours of microplate processing with no need for user invention. The Guava EasyCyte is a five-parameter microplate cytometer that is flexible and ultra-compact. As it requires only a few microlitres of sample volume, it saves precious cells, reagents and compounds. The system is easy to use, with results being generated after less than a dayÆs training. The Guava PCA- 96 offers turnkey operation in an integrated system consisting of the compact instrument, software to automatically analyse and archive data, and optimised reagents. The system simplifies cell monitoring and screening, as only a few microlitres of samples are required for each experiment, saving cells and reagents and reducing potentially hazardous biological waste.