Research into leucocyte function

ILT4 is expressed selectively on myelomonocytic cells and binds to classical and non-classical human leucocyte antigen (HLA) class I molecules. ILT4 is believed to play various roles in cellular function, including the modulation of APC functions (eg antigen uptake, migration and cytokine production), control of inflammatory response and maternal tolerance against the fetal semiallograft.

CD85d-PE is offered exclusively by Beckman Coulter and completes the company’s list of clones against immunoglobulin (Ig)-like transcripts.

The new CD85d-PE antibody is useful in basic research of leucocyte function, dendritic cells, immunosuppression, tolerogenicity and maternofetal tolerance. Its ability to identify tolerogenic cells makes the new antibody particularly valuable for transplant and cancer research. It is also applicable in clinical research on autoimmunity. CD85d-PE delivers advantages over other antibodies in applications where control of tolerogenicity is important.

The preformulated, standardised IOTest CD85d-PE monoclonal antibody is provided in 100-test vials. Beckman Coulter offers a number of reagents, controls and markers that can be used with this new antibody, which is approved for research use only.