Early detection of bowel cancer

Most sporadic colorectal cancers follow a well-recognised progression from normal cells through adenoma to cancer, driven by mutations in a small number of genes. RanplexCRC can detect 28 mutations from four key genes in cancer or precancer cells shed into the bowel. Selected mutations present in APC, KRAS, BRAF and Tp53, along with wild-type control sequences, are represented on two biochips and are detected using Randox’s biochip array analysers.

The Randox family of biochip array analysers are immunoassay testing platforms that work by combining panels of related tests on a single biochip. The chemiluminescent endpoint is detected by a CCD-camera and quantified by image-processing software.

www.randox.com