Three-dimensional imaging aids cancer research

Preston-based Image Solutions has launched a confocal quantitative image (CQI) cytometer from Japanese company Yokogawa. The CQI can accurately quantify the morphological features of live individual cells, clusters such as spheroids, colonies and also tissue sections without the time-consuming need to separate cells or remove them from a culture dish.

Unlike conventional devices, the CQ1 uses a microlens enhanced dual Nipkow disk confocal optical system to obtain accurate 3D images of cell morphological features and measure cell position, resulting in more accurate and reproducible data by maintaining the original biological functions and features of the cells in cell clusters. It is also possible to continue culture experiments for repetitive measurements in order to examine chronological changes. A fully customised CQ1 system can also be integrated with external systems for robotic culture dish handling.
       The CQI is growing in importance in areas such as regenerative medicine, cell quality evaluation for drug discovery, pharmacology, biopsy evaluation and the study of cancer and other diseases where it is essential to quantify live cell morphological features accurately without interfering with the cell’s biological functions. It is also becoming important in other types of cell-related research that involve fluorescence in situ hybridisation (FISH).

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