The antibody 34bE12, available from A Menarini Diagnostics, recognises cytokeratin 1, 5, 10 and 14. It reacts with squamous and adenosquamous cell carcinomas, while adenocarcinoma is negative. In normal tissue, 34bE12 stains stratified epithelia, myoepithelial cells and basal cells in the prostate gland and bronchus. Thus, it is useful as a differential marker for squamous carcinoma and adenocarcinoma as well as for benign and malignant tumours of the prostate gland.
High molecular weight cytokeratins
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