A Personal DeltaVision (DV) cell microscopy imaging system supplied by Image Solutions UK is assisting scientists at Cancer Research UK to understand how tumours develop drug resistance. The system is being used by a team of researchers based in the Translational Cancer Therapeutics (TCT) laboratory, using parallel clinical trial and functional genomics approaches to develop new predictive tools that will improve the prognosis of patients with solid tumours.
“There are a number of reasons why the Personal DV system is very useful to us,” said TCT Research Fellow Dr. Sarah McClelland. “First, it allows us to follow processes within the cell in real time. This means we can correlate observed behaviour in a cell at a particular moment in time with what has happened previously. Second, the Personal DV exposes the cells we are observing to very low levels of light, which is important because the intense light required by other imaging systems would damage our cells. The Personal DV allows us to perform long-term imaging, over two to three days, which is possible due to the CO2 perfusion and acrylic chamber that form the microscope environmental chamber. This is very useful in our work,” she added.
The Personal DV is the junior system in Applied Precision’s family of live cell microscopy imaging range. It is designed specifically for the budget-minded facility with limited space. Combined with a xenon light source and a newly redesigned 10-position excitation filter wheel and six-position emission filter wheel, the Personal DV provides fast multi-channel image acquisition.
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