Obstetric cholestasis is a serious complication of pregnancy that can result in an increased risk of premature birth or even stillbirth. It is vital, therefore, that women with the disease are monitored carefully using the latest complete testing package.
Bile acids are water-soluble, amphipathic end-products of cholesterol metabolism and are involved in liver, biliary and intestinal diseases. They are formed in the liver and are absorbed actively from the small intestine, with each molecule undergoing multiple enterohepatic circulations before ultimately being excreted.1
Intrahepatic cholestasis of pregnancy
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder. Symptoms include pruritus and jaundice, with elevated total bile acids and/or serum transaminases. It usually affects women during the second and third trimester of pregnancy.2,3
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