Applying liquid chromatography-mass spectrometry to clinical research

Thermo Fisher Scientific and Cedars-Sinai, a leading non-profit academic healthcare organisation, have entered into a collaboration to develop a pathway to precision medicine through the development of robust, reliable and sensitive liquid chromatography mass spectrometry (LC-MS)-based workflows for clinical research applications.

Bringing together Thermo Fisher’s leading LC-MS technology with the expert insights of Cedars-Sinai’s physicians and clinical research scientists, this initiative aims to provide clinical research laboratories with specific and sensitive LC-MS-based workflows that will deliver increased confidence in data while detecting and analysing novel or known protein-based biomarkers within biological matrices.

"As the pathway to precision medicine advances in the laboratory, reliable and routine analytical workflows will be essential to quantify targeted and untargeted proteins and peptides in clinical samples with greater ease and sensitivity," said Bradley Hart (senior director, clinical marketing, chromatography and mass spectrometry, Thermo Fisher Scientific). "New LC-MS-based methods will be developed to deliver high-quality and confident results regardless of user expertise and experience for laboratories seeking to identify novel biomarkers and monitor biotherapeutics, ultimately helping clinical research teams track and improve outcomes."

Dr Jennifer Van Eyk, principal investigator for research, and director of the Advanced Clinical Biosystems Institute in the Department of Biomedical Sciences at Cedars-Sinai, said, "Thermo Fisher shares our vision for helping clinical research teams set new standards for excellence and innovation in patient care through precision medicine. The goal is to develop advanced LC-MS-based workflows for the untargeted screening and targeted quantitation of protein-based biomarkers for critical disease states, which hold the potential to benefit not only our own patients, but also the wider clinical community."