Bio-Rad Laboratories has expanded its precision oncology research portfolio with new tools designed to support mutation detection research, liquid biopsy workflows, tumor-informed assay development, molecular residual disease (MRD) research, and multiplex biomarker analysis.
Expanding the oncology assay menu available for the QX700 systems, Bio-Rad has launched the QX700 ddPCR EGFR Exon 19 Deletions Screening Kit and QX700 ddPCR KRAS G12/G13 Screening Kit. The new assays optimised for use with the QX700 systems are intended to support research involving EGFR and KRAS mutations across multiple solid tumour research applications.
Fully compatible across Bio-Rad’s family of QX systems, Dark Probe Mutation Detection Assays are additional tools that can help advance translational research in oncology applications, especially for liquid biopsy mutation detection and monitoring in liquid, MRD, liquid biopsy and translational research workflows. Designed to replace the wild-type fluorescent probe in existing ddPCR workflows, quencher-only dark probes suppress wild-type background and free a detection channel allowing up to four mutation targets to be analyzed in a single well, increasing multiplexing capabilities and reducing demand for sample volume.
Thirteen oncology focused ddPLEXCrystalTag ddPCR Assays and CrystalTag Reporters will be available soon. Bio-Rad’s CrystalTag technology separates target recognition from signal generation, enabling flexible assay design and multiplexed detection of up to 21 targets in a single reaction well on the QX700 platform, and supporting efficient development of custom research workflows. These new solutions, including assays for mutation detection of the ESR1 mutation, KRAS mutations, and HPV, enable high-plex ddPCR research across translational research, biomarker discovery, biopharmaceutical research, and advanced multiplex assay development.
“With this expanded menu of QX700 ddPCR assays and technologies, researchers can design more powerful multiplex assays and analyse biomarkers with highly sensitive, absolute quantification, all in scalable, streamlined workflows,” said Steve Kulisch, Vice President Product Management, Digital Biology Group, Bio-Rad Laboratories. “Together with our continued investment in CrystalTag technology, this launch underscores Bio-Rad’s commitment to advancing oncology research.”
Visit bio-rad.com/DropletDigitalPCRPortfolio to learn more about Bio-Rad’s comprehensive portfolio of digital PCR instruments, consumables, and assays. ddPCR assays manufactured by Bio-Rad Laboratories are for Research Use Only (RUO) and are not intended for use in diagnostic procedures.