Dako has launched a full diagnostic panel of antibodies to detect mismatch repair proteins, which are used routinely for the diagnosis and study of colorectal cancer and hereditary non-polyposis colorectal carcinoma (HNPCC or Lynch syndrome). Absence of staining with one or more antibodies in the panel may indicate lack of functioning mismatch repair proteins.
These nuclear proteins are involved in the DNA mismatch repair (MMR) pathway used by normal proliferating cells to repair mutations that may occur during DNA replication. Loss of function of the MMR proteins results in an increased mutation rate and contributes to the development of sporadic colorectal carcinoma.
The panel includes MSH2, MSH6, PMS2 and MLH1 antibodies. All show high sensitivity and excellent specificity for immunohistochemistry and are available either as concentrates (0.2 mL or 1 mL) or in ready-to-use format optimised with EnVision FLEX for use on the Dako Autostainer Link 48.
www.dako.com
