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OXA-48-, KPC- & NDM-type carbapenemase-producing organism detection

Multidrug resistance exhibited by a range of microorganisms is a growing problem, a prime example being that resulting from carbapenemase production. Here, Gemma Vanstone and colleagues assess the value of the RESIST-3 O.K.N. lateral-flow immunochromatography assay.

Carbapenemase-producing organisms (CPOs) are multidrug-resistant and have been shown to be associated with increased morbidity and mortality. Rapid detection can guide clinical management and allow implementation of appropriate infection control procedures.

The Royal Free London NHS Foundation Trust is a tertiary referral centre with a diverse, international patient population. In April 2013, the Royal Free implemented a CPO screening programme of selected universal screening in some areas (intensive care, private, renal and liver units), together with risk factor-based screening in others (haematology, oncology, stroke and infectious disease units). In addition, any patients with identified risk factors for CPO and contacts of positive cases are screened.

The most commonly detected genotype at the Royal Free is OXA-48, followed by NDM, VIM, KPC and OXA-23. In addition, occasionally more unusual types are isolated, including IMP, IMI and GES-5.

Carbapen

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Upcoming Events

Haemovigilance Past, Present and Future

Regency Suite, Brighton Hilton Metropole
6–8 July

BSMT - The Genomic and Microbiology Revolution: In Technology We Trust?

Royal Air Force Museum, Hendon, London
19 July 2022

Arab Lab Live 2022

Dubai International Convention & Exhibition Centre Dubai World Trade Centre - Trade Centre - Trade Centre 2 - Dubai - United Arab Emirates
24 - 26 October 2022

Lab Innovations 2022

Hall 2 NEC, Birmingham
2 & 3 November 2022

MEDICA 2022

Messe Düsseldorf D-40474 Düsseldorf, Stockumer Kirchstraße 61
14 - 17 November 2022

Access the latest issue of Pathology In Practice on your mobile device together with an archive of back issues.

Download the FREE Pathology In Practice app from your device's App store

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