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Pre-eclampsia testing: support for the use of the sFlt-1/PlGF ratio

Results of recent studies into pre-eclampsia testing have informed the latest National Institute for Health and Care Excellence guidance, which recommends use of the sFlt-1/PlGF ratio test to help rule-out this form of gestational hypertension.

Hypertensive disorders, such as pre-eclampsia (PE), affect approximately 13.5%1 of pregnancies in the UK, which equates to around 80,000 women. Pre-eclampsia occurs in approximately 2–3% of pregnancies in the UK1,2 and is the most common hypertensive disorder during pregnancy globally, resulting in substantial maternal and fetal mortality and morbidity.2,3

A UK study reported that one-third of severe maternal morbidity was a consequence of hypertensive conditions.4 The cause of pre-eclampsia is not fully understood, but there is growing evidence that angiogenic factors such as placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) play a major role in development of the condition.

Improved understanding leads to diagnostic advances

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Upcoming Events

USCAP 113th Annual Meeting

Baltimore Convention Center, Baltimore, Maryland, USA
23-28 March, 2024

Pathology Horizons 2024

MacDonald Bath Spa Hotel, Bath
18-20 April, 2024

Diagnostics North East Conference 2024

The Catalyst, Newcastle upon Tyne
19 April, 2024

ECCMID 2024 - European Congress of Clinical Microbiology and Infectious Diseases

Fira Gran Via, 08038 Barcelona, Spain
27-30 April 2024

British Society for Microbial Technology Annual Microbiology Conference

UK Health Security Agency, Colindale, London
2 May 2024

EQA Reports: Interpreting Key Information & Troubleshooting Tips

ONLINE - Zoom
Thursday 16th May 2024

Access the latest issue of Pathology In Practice on your mobile device together with an archive of back issues.

Download the FREE Pathology In Practice app from your device's App store

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