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Cell-free DNA and testing for cancer: a brief look in the literature

Recent national news focused on the role that cell-free DNA (cfDNA) testing may have in detecting many different types of cancer. Here, a small selection from the current literature highlights future possibilities and some potential problems.

Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA

Liu MC, Oxnard GR, Klein EA, Swanton C, Seiden MV; on behalf of the CCGA Consortium. Ann Oncol 2020 Mar 30. doi.org/10.1016/j.annonc.2020.02.011 (Epub ahead of print)

Early cancer detection could identify tumours at a time when outcomes are superior and treatment is less morbid. This prospective case-control sub-study  (from NCT02889978 and NCT03085888) assessed the performance of targeted methylation analysis of circulating cell-free DNA (cfDNA) to detect and localise multiple cancer types across all stages at high specificity.

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Upcoming Events

Pathology Horizons 2024

MacDonald Bath Spa Hotel, Bath
18-20 April, 2024

Diagnostics North East Conference 2024

The Catalyst, Newcastle upon Tyne
19 April, 2024

ECCMID 2024 - European Congress of Clinical Microbiology and Infectious Diseases

Fira Gran Via, 08038 Barcelona, Spain
27-30 April 2024

British Society for Microbial Technology Annual Microbiology Conference

UK Health Security Agency, Colindale, London
2 May 2024

EQA Reports: Interpreting Key Information & Troubleshooting Tips

ONLINE - Zoom
Thursday 16th May 2024

Participants’ Meeting: UK NEQAS Immunology, Immunochemistry & Allergy

Sheffield Hallam University, City Campus, Howard Street, Sheffield
24th May 2024

Access the latest issue of Pathology In Practice on your mobile device together with an archive of back issues.

Download the FREE Pathology In Practice app from your device's App store

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