Liquid biopsy applications: a selection of current research interest

Liquid biopsy is a minimally invasive approach to determine the presence of malignant tumours, looking for evidence of tumour cells and cancer cell DNA circulating in blood, and potentially also in body fluids such as urine, sputum and saliva. Here, Pathology in Practice Science Editor Brian Nation compiles a small selection of recent research interest in this fascinating field.

Liquid biopsy: current technology and clinical applications

Nikanjam M, Kato S, Kurzrock R. J Hematol Oncol. 2022 Sep 12; 15 (1): 131. doi:10.1186/s13045-022-01351-y.

Liquid biopsies are increasingly used for cancer molecular profiling that enables a precision oncology approach. Circulating extracellular nucleic acids (cell-free DNA [cfDNA]), circulating tumour DNA (ctDNA), and circulating tumour cells (CTCs) can be isolated from the blood and other body fluids. 

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