As recent research illustrates, platelet function and platelet counting have wider application than simply their role in the study of haemostasis. Here, Pathology in Practice Science Editor Brian Nation compiles a selection of current interest in the medical literature.
The dynamic role of platelets in cancer progression and their therapeutic implications.
Li S, Lu Z, Wu S et al. Nat Rev Cancer. 2024 Jan; 24 (1): 72–87. doi:10.1038/s41568-023-00639-6.
Systemic antiplatelet treatment represents a promising option to improve the therapeutic outcomes and therapeutic efficacy of chemotherapy and immunotherapy due to the critical contribution of platelets to tumour progression. However, until recently, targeting platelets as a cancer therapeutic has been hampered by the elevated risk of haemorrhagic and thrombocytopenic (low platelet count) complications owing to the lack of specificity for tumour-associated platelets.
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