Phaeochromocytomas and paragangliomas develop from neuroendocrine chromaffin cells. Tumours developing from such cells are called phaeochromocytomas if found in the medulla of the adrenal gland, or paragangliomas if growing elsewhere in the body. Here, Pathology in Practice Science Editor Brian Nation looks at a selection of current research in the literature.
Update on the diagnosis of the pheochromocytoma
Achote E, Arroyo Ripoll OF, Araujo-Castro M. Hipertens Riesgo Vasc. 2025 Jan-Mar; 42 (1): 43–51. doi:10.1016/j.hipert.2024.08.001. Epub 2024 Oct 10.
Phaeochromocytoma is a rare neuroendocrine tumour that develops from chromaffin cells in the adrenal medulla and is characterised by the excessive production of catecholamines and their metabolites. Diagnostic confirmation is performed by detecting elevated levels of catecholamines and/or their metabolites in plasma or 24-h urine.
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