Chip technology for small molecules

Protea Biosciences recently presented a new chip-based technology at Pittcon in New Orleans. This nanopost array technology, called REDIchip (resonance-enhanced desorption ionisation) was invented in the laboratory of Dr Akos Vertes, in the Department of Chemistry, The George Washington University. The chip is designed to be used for mass spectrometric analysis on matrix-assisted laser desorption/ionisation (MALDI) platforms without the need for matrix.

“REDIchips provide a solution to researchers interested in detecting small molecules without the common interference of chemical matrix. The ability to detect and quantitate small molecules reproducibly is made possible due to the structured nanopost array (NAPA) present in the silicon chip,” said Haddon Goodman, Protea’s imaging programme manager. “The REDIchip enables more sensitive quantitation for small molecules than traditional workflows using a robust and reproducible matrix-free environment.”

Protea’s REDIchip technology will be compatible with various MALDI systems, and it will allow rapid and reproducible sample analysis of small molecules by laser desorption ionisation.


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