Two grants aim to tackle sepsis

MediSieve is receiving two grants from Innovate UK, worth a total of around £1.56 million. One grant will progress development of a severe sepsis product, developing five magnetic particles to remove different sepsis targets. Another SRBI grant enables focus on one of those particles and how it can be used to remove antimicrobial-resistant (AMR) bacteria from a patient’s bloodstream.

Sepsis causes the body to attack its own organs and tissues. It kills 44,000 individuals in the UK and affects 20 million people globally each year. Six million of these are babies and children. Sepsis research is of high priority because, with mortality over 30% and antibiotic therapies increasingly at risk from antimicrobial resistance, its human and economic impact have never been of more concern. 

The Biomedical Catalyst (BMC) project aims to develop a multi-target magnetic blood filtration treatment that is complementary to antibiotics, working to address the LPS and cytokines that antibiotics release and which exacerbate the immune response and elevate cytokine levels. The SBRI project explores an alternative to antibiotics to reduce the level of bacteria in the bloodstream of AMR sepsis patients, with the added benefit of LPS removal as a secondary effect.

Speaking about the biomedical catalyst grant, Dr George Frodsham (pictured), CEO and founder of MediSieve, said: "Our technology is like dialysis, circulating a patient's blood through an external loop to remove disease-causing targets.”

www.medisieve.com

 

Other news

Visualise No Malaria

Upcoming Events

Clinical and Laboratory Haemostasis 2019

The Atrium Conference Centre, Sheffield Hallam University
5-6 June 2019

Ist International Blizard/QMUL Tuberculosis Symposium

Bearsted Lecture Theatre, Alexandra Wing, Queen Mary University of London - Whitechapel
26-27 June 2019

The Oxford Haematology in Obstetrics Postgraduate Course

St Edmund Hall, Queen's Lane, Oxford OX1 4AR
9-11 September 2019

IBMS Biomedical Science Congress

ICC, Birmingham
22-25 September 2019

Latest Issue

Pathology In Practice

Pathology In Practice

Apr 2019

Reducing exposure to antimicrobial agents

Register now to apply for regular copies of Pathology In Practice and free access to premium content, as well as our regular newsletters.