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Expression of PRAME in melanocytic lesions: significance and evaluation

Immunohistochemistry is a vital tool in the classification of melanocytic skin lesions. Here, Karolina Wojcik and colleagues assess PRAME expression as a new marker in recognising and distinguishing the malignant melanomas from atypical naevi.

According to Cancer Research UK statistics,1 malignant melanoma is the fifth most common cancer in the UK, and each year around 16,000 people are diagnosed with this deadly skin cancer. Cutaneous melanocytic lesions can be divided into benign and atypical melanocytic naevi, and the most aggressive type of skin malignancy, malignant melanoma (MM).

This study aims to evaluate the staining pattern of PRAME (PReferentially expressed Antigen in MElanoma) expression in melanocytic tumours, and highlights PRAME expression in primary and metastatic melanomas as well as other melanocytic lesions. This research looks at the potential to explore PRAME expression in melanocytic naevi, which could prove an invaluable input to distinguish the benign/atypical naevi from melanomas.

PRAME is a melanoma-associated antigen first identified through analysis of the specificity of T-cell clon

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Upcoming Events

Haemovigilance Past, Present and Future

Regency Suite, Brighton Hilton Metropole
6–8 July

BSMT - The Genomic and Microbiology Revolution: In Technology We Trust?

Royal Air Force Museum, Hendon, London
19 July 2022

Arab Lab Live 2022

Dubai International Convention & Exhibition Centre Dubai World Trade Centre - Trade Centre - Trade Centre 2 - Dubai - United Arab Emirates
24 - 26 October 2022

Lab Innovations 2022

Hall 2 NEC, Birmingham
2 & 3 November 2022

MEDICA 2022

Messe Düsseldorf D-40474 Düsseldorf, Stockumer Kirchstraße 61
14 - 17 November 2022

Access the latest issue of Pathology In Practice on your mobile device together with an archive of back issues.

Download the FREE Pathology In Practice app from your device's App store

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