RECENT NEWS

Detecting gene mutations in lung cancer

Detecting gene mutations in lung cancer

A simple test that can detect gene mutations in tumour DNA from blood samples is giving new choices to lung cancer patients with faster diagnosis and improved access to life-changing drugs. Traditionally, lung cancer diagnosis has relied solely on lung biopsies, an invasive procedure which many patients are too unwell to tolerate. However, a new EGFR mutation test enables the use of a liquid biopsy from blood alongside or instead of the lung biopsy to identify genetic abnormalities in the EGFR gene associated with lung cancer.
Congress: An investment in learning and development

Congress: An investment in learning and development

An investment in learning and development exactly sums up the IBMS Congress, which returns to the International Convention Centre in Birmingham later this month (24–27 September). Change is happening in pathology at a pace not previously encountered, and many biomedical scientists are extending their knowledge and skills beyond their own specialty as services and departments merge and technologies are shared across disciplines.
Measurement uncertainty and IQC

Measurement uncertainty and IQC

The August issue of Pathology in Practice saw the third in a series of articles on measurement uncertainty (MU) by Stephen MacDonald, in which he considered standard uncertainty, where all contributors are expressed in a common currency. In the fourth article in this important series, scheduled to appear in the November issue, he will be walking through uncertainty budgeting with internal quality control (IQC) as the major contributor. This will be applicable to a large portion of the assays in every laboratory’s repertoire, and will compare a number of different (but related) methods for determining the MU. In the fifth and following article, Stephen will approach MU in assays where multiple inputs contribute to uncertainty.
Digital pathology at the ECP 2017

Digital pathology at the ECP 2017

Digital and computational pathology is opening up a new dimension for pathology services. Philips Digital Pathology invites those attending the European Congress of Pathology (ECP; 2–6 September) in Amsterdam to visit Booth 44/45 for hands-on experience as well as tips from Dr Alexi Baidoshvilli (LabPON, The Netherlands). LabPON was one of the first laboratories to move to a fully digital histopathology workflow, and Dr Baidoshvili (pictured) believes that digital pathology will open up the potential for building “a global network of experts communicating remotely”.
Innovative microscopy recognised by award

Innovative microscopy recognised by award

Phasefocus is the recipient of a 2017 Microscopy Today Innovation Award for its Livecyte Kinetic Cytometer system. Livecyte enables quantitative label-free, live-cell analysis of single and multiple cell types in heterogeneous cell populations using ptychographic quantitative phase imaging (QPI).
Next-generation lateral-flow immunoassays on show

Next-generation lateral-flow immunoassays on show

BBI Solutions recently showcased its Morffi signal enhancement technology and Novarum smartphone reader at the Next Generation Dx Summit, held in Washington DC. For BBI, a manufacturer of raw materials and finished test platforms for the in vitro diagnostics market, it was the perfect opportunity to demonstrate how Morffi can improve sensitivity, specificity and time to result for lateral-flow immunoassays.
Expanded IVD portfolio for near-patient testing

Expanded IVD portfolio for near-patient testing

Philips recently announced the expansion of its IVD portfolio at EuroMedLab 2017 as part of the drive to deliver on-the-spot testing for critical care patients. Marcel van Kasteel, CEO Philips Handheld Diagnostics, explained that laboratory managers were getting closer to clinical leads and cardiologists in understanding ways of collaborating to resolve unmet needs, especially around crowding and workflow in the emergency department (ED).
Diagnostics products and services partnership

Diagnostics products and services partnership

North West London Pathology (NWLP), hosted by Imperial College Healthcare NHS Trust, and Abbott recently signed a $252 million managed equipment services contract for the supply of all analytical equipment and consumables, including Abbott's Alinity ci and Alinity h series diagnostic instruments, as well as professional services and informatics solutions known as AlinIQ.
Building on measurement uncertainty assessment

Building on measurement uncertainty assessment

The August issue of Pathology in Practice features the third in a series of articles on the assessment of uncertainty of measurement, and this month Stephen MacDonald considers standard uncertainty, where all contributors are expressed in a common currency.
Dynamic DNA helps protect against gene damage

Dynamic DNA helps protect against gene damage

Researchers have identified properties in the protective structure of DNA that could transform the way scientists think about the human genome. Molecules involved in DNA’s supportive scaffolding go through dynamic and responsive changes to shield against mutations, recent research has shown. Experts say this finding is crucial to understanding DNA damage and genome organisation, and could impact current thinking on DNA-linked diseases, including cancers.
Mycoplasma genitalium detection and azithromycin resistance testing

Mycoplasma genitalium detection and azithromycin resistance testing

SpeeDx has entered into an agreement with Cepheid for distribution of its PlexPCR and ResistancePlus molecular diagnostic products in key markets throughout Europe. The agreement, covering Germany, France, Italy and the UK, will increase coverage for the ResistancePlus MG test, the first CE/IVD test for Mycoplasma genitalium to combine detection with testing for azithromycin resistance.
Procalcitonin expands chemistry menu

Procalcitonin expands chemistry menu

Beckman Coulter Diagnostics has entered a partnership with Diazyme Laboratories that allows customers access to a procalcitonin (PCT) assay, an important marker for the detection and management of bacterial infections and sepsis. The high-quality, fully automated PCT assay is available for use with Beckman Coulter AU analysers (models 480, 680 and 5800).
Haemoglobinopathies: screening by capillary electrophoresis

Haemoglobinopathies: screening by capillary electrophoresis

The two major roles of the haemoglobinopathy laboratory are the recognition of clinically important variant haemoglobins and the accurate and precise quantification of haemoglobin A2 for the diagnosis of β-thalassaemia heterozygosity. Both can be met by capillary electrophoresis (CE), which is now regarded as a suitable technique for the diagnosis of β-thalassaemia and the detection of variant haemoglobins.
Online short courses in the biomedical sciences

Online short courses in the biomedical sciences

Biomed Online offers a well-established programme of M-level short courses for MSc, PG Dip, PGCert qualifications. These are fully supported by tutors over 12 weeks and cover specialist healthcare and quality management topics for the professional development of biomedical scientists and workplace practitioners.
Cryo-EM uncovers the structure of tau filaments in Alzheimer's

Cryo-EM uncovers the structure of tau filaments in Alzheimer's

Researchers at the Medical Research Council Laboratory of Molecular Biology (LMB) have revealed the atomic structures of one of the two types of abnormal filament which leads to Alzheimer's disease. The researchers, whose study was published recently in the journal Nature, believe the structures uncovered could also suggest how tau protein may form different filaments in other neurodegenerative diseases.
Meeting of Minds

Meeting of Minds

Congress – in the UK the word means a large, formal meeting of delegates and representatives at which ideas are discussed and information is exchanged.
Lab Innovations returns to NEC Birmingham

Lab Innovations returns to NEC Birmingham

Lab Innovations will return for its sixth consecutive year on 1–2 November 2017 at the NEC, Birmingham. With the largest gathering of laboratory suppliers in the UK, this free-to-attend show has much to offer professionals across a wide range of sectors, from pharmaceuticals to food and drink.
Predicting universal anti-influenza drugs

Predicting universal anti-influenza drugs

University of Hertfordshire researchers have developed a new concept which could lead to the discovery of universal anti-influenza drugs. It is hoped that this new way of including more than 12,000 influenza virus gene sequences will ensure that predicted antivirals are effective against most influenza virus strains. The findings were published recently in the journal Virology.
Re-engineered vancomycin offers hope in fight against antimicrobial resistance

Re-engineered vancomycin offers hope in fight against antimicrobial resistance

Experts have repeatedly warned that medical science is on the cusp of a ‘post-antibiotic era’, where some infections could become untreatable. Now, scientists in the USA have re-engineered a new version of vancomycin in a bid to wipe out one of the world's most threatening microorganisms. The new antibiotic is designed to be ultra-tough and appears to be a thousand times more potent, according to research published in Proceedings of the National Academy of Science USA.
Blood filtration extended to the fight against leukaemia

Blood filtration extended to the fight against leukaemia

MediSieve, the company behind a revolutionary magnetic sieve that filters out malaria-infected cells directly from a patient’s bloodstream, is now developing new methods to combat leukaemia. Following the successful development of its magnetic filter device, which will soon move into clinical trials, MediSieve is now commencing research into the treatment of other conditions using magnetic particles to target specific disease-causing components in blood.

Upcoming Events

Update Course in Gynaecological Cytology

London Regional Cytology Training Centre, Level 6X, St Marks Building, Watford Road, Harrow HA1 3UJ
12-14 December 2018

Managing Cultural Differences in the Workplace

The Holiday Inn - Kensington Forum, 97 Cromwell Road, London SW7 4DN
21 January 2019

British Society for Haematology Paediatric Symposium

Royal College of Paediatrics and Child Health, 5-11 Theobalds Road, London WC1X 8SH
14 February 2019

Challenges in the clinical biochemistry laboratory and beyond

The Royal College of Pathologists
28 February 2019

British Society for Haematology 59th Annual Scientific Meeting

SEC Glasgow
1-3 April 2019

Latest Issue

Pathology In Practice

Pathology In Practice

Dec 2018

Molecular diagnostics and LAMP technology

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