RECENT NEWS

Fluorescent biosensors as tools for drug therapeutics

Fluorescent biosensors as tools for drug therapeutics

Researchers in the School of Pharmacy at the University of Nottingham have been using Dolomite Microfluidic’s chips to enhance their work on drug encapsulation and therapeutic delivery. Dr Veeren Chauhan, working with Dr Jonathan Aylott and Dr Amjad Selo, explained: “We have been using Dolomite chips since the end of 2017 and have continuously manufactured an array of uniformly-sized PLGA (poly[lactic-co-glycolic acid]) particles. We can fine-tune the system set-up, depending on the downstream requirements, to provide a consistent particle shape and size, as well as control drug release parameters. These attributes are key to ensuring the correct dose of drug is maintained, achieving maximum therapeutic benefit without unwanted side-effects.”
New Cytocell facility to open in Cambridge

New Cytocell facility to open in Cambridge

Oxford Gene Technology (OGT) is expanding its Cytocell operations with a move to a new facility in Cambridge, UK. Cytocell, OGT’s fluorescence in situ hybridisation (FISH) probe brand, will be moving into the significantly larger facility on the prestigious Cambridge Science Park, due to expansion of the organisation, current sales volumes and predicted sales growth. In addition to investing in OGT by expanding Cytocell’s operational footprint, OGT’s parent company, Sysmex, is demonstrating its confidence in the UK by establishing the new premises.
HIV-1 assay receives two CE marks, for viral load and early infant diagnosis

HIV-1 assay receives two CE marks, for viral load and early infant diagnosis

Hologic has announced that its Aptima HIV-1 Quant Dx assay has received two new CE marks in Europe – for early infant diagnosis (EID) and for testing dried blood spots (DBS). This means the assay can be used qualitatively to detect HIV-1 RNA as an aid in the diagnosis of HIV-1-infected infants under 18 months old, and to test an additional sample type (DBS) to monitor viral load and disease progression in HIV-1- infected individuals in European and African countries. It is the first and only dual-claim assay for both viral load and early infant diagnosis.
D-dimer POCT for deep vein thrombosis

D-dimer POCT for deep vein thrombosis

Radiometer’s AQT90 FLEX analysers have been used in a successful trial to asses D-dimer point-of-care testing (POCT) for suspected lower limb deep vein thrombosis (DVT), in which a reduction in patient waiting times of up to 75% was achieved.
IFBLS: 64 years of good laboratory practice

IFBLS: 64 years of good laboratory practice

The year 2018 marked the 64th anniversary of the founding of the International Association of Medical Laboratory Technologists (IAMLT), now named the International Federation of Biomedical Laboratory Sciences (IFBLS). President Elect Alan Wainwright reports.
Two grants aim to tackle sepsis

Two grants aim to tackle sepsis

MediSieve is receiving two grants from Innovate UK, worth a total of around £1.56 million. One grant will progress development of a severe sepsis product, developing five magnetic particles to remove different sepsis targets. Another SRBI grant enables focus on one of those particles and how it can be used to remove antimicrobial-resistant (AMR) bacteria from a patient’s bloodstream.
The Periodic Table: an anniversary of organisation

The Periodic Table: an anniversary of organisation

The United Nations has designated 2019 as the International Year of the Periodic Table to celebrate one of the most significant achievements in science. Next month it will be 150 years since the Russian scientist Dmitri Mendeleev took all of the known elements and arranged them into a table (pictured).
Scientists identify ‘origin’ of cancer spread

Scientists identify ‘origin’ of cancer spread

Scientists in the UK claim to have identified a cancer cell from which all cancer growth starts. The discovery of the cell, which they are calling ‘the cell of origin’ sheds new light on what fuels cancer growth and potentially how to stop it. Lead researcher Professor Michael P Lisanti said: “If, as we believe, we have found the beginning of the road, we may have to press the reset button on how we treat cancer with drugs.”
Future Leaders in Innovation, Enterprise and Research

Future Leaders in Innovation, Enterprise and Research

The Academy of Medical Sciences has announced the first participants of its novel Future Leaders in Innovation, Enterprise and Research (FLIER) Programme. Seventeen participants from organisations across the life sciences landscape have been selected for the first round of the prestigious FLIER leadership programme.
Healthcare: a two-day look to the future

Healthcare: a two-day look to the future

A former Secretary of State for Health, the Rt Hon Patricia Hewitt, is confirmed to give a welcome address at Future Healthcare International Exhibition and Conference at Olympia. Future Healthcare 2019 is organised in association with UKIHMA, a UK government trade promotion organisation jointly funded by the Department for International Trade, the Department of Health and NHS England.
Respiratory infections: revised BSMT conference programme

Respiratory infections: revised BSMT conference programme

The next British Society for Microbial Technology (BSMT) Annual Scientific Conference, entitled Respiratory Microbiology – A Day of Inspiration, will take place on Thursday 16 May 2019 at the RAF Museum Hendon. Some revisions to the programme have been made as outlined below.
Statistical quality control: setting IQC targets

Statistical quality control: setting IQC targets

The third in his Pathology in Practice series of articles on internal quality control, which will appear in the February 2019 issue, will see Stephen MacDonald continue his overview of process design with a look at defining process stability and setting target values.
Fear of side effects main reason for choosing not to vaccinate

Fear of side effects main reason for choosing not to vaccinate

The Royal Society for Public Health (RSPH) has published a report revealing the extent to which social media propagates misinformation about vaccinations, and that the perceived risks of side effects are the key concern among those who choose not to vaccinate. While all vaccines have potential side effects, in reality they only affect some people – and are typically mild, short-lived, and far outweighed by the benefits of immunisation.
Combined diagnostic and antimicrobial susceptibility test enables guided therapy for gonorrhoea

Combined diagnostic and antimicrobial susceptibility test enables guided therapy for gonorrhoea

UK patients with N. gonorrhoeae (GC) now have the option of receiving the cheap and easily-administered oral antibiotic ciprofloxacin thanks to updated treatment guidelines and the availability of a molecular diagnostic and antimicrobial susceptibility test (AST). The new test can simultaneously diagnose gonorrhoea and provide information on whether or not a patient will respond to ciprofloxacin.
Clinical flow cytometry supported by new 10-colour system

Clinical flow cytometry supported by new 10-colour system

Beckman Coulter has launched the ClearLLab 10C System for the clinical flow cytometry laboratory. The new system includes the first 10-colour CE-IVD panels of immunophenotyping reagents for both lymphoid and myeloid lineages. The ClearLLab 10C System incorporates the company’s new Kaluza C software to streamline and standardize clinical QC reporting to international guidelines.
Childhood leukaemia distinct from adult disease

Childhood leukaemia distinct from adult disease

Scientists have identified and modelled a distinct biology for paediatric acute myeloid leukaemia (AML), one of the major causes of death in children. The breakthrough research, from the University of Glasgow’s Institute of Cancer Sciences, published in Nature Communications, significantly advances understanding of the disease and provides potential for developing specific treatment strategies for this childhood cancer, which is currently treated with therapies extrapolated from adult practice.
Gonorrhoea and antimicrobial resistance

Gonorrhoea and antimicrobial resistance

So-called super-gonorrhoea has hit the headlines once again with a report of two patients infected with a version of the sexually transmitted disease that is resistant to the first-choice antibiotics, which is a combination of azithromycin and ceftriaxone. The cases are not related to the world's ‘worst case’, which was detected in the UK in 2018 after the patient returned from a trip to South East Asia.
Congress 2019: new content and more choice introduced

Congress 2019: new content and more choice introduced

Congress 2019 is going to offer the most ambitious programme the Institute of Biomedical Science has ever hosted, which will be published at the beginning of February. Owing to the success in 2017 of the new Sunday programme, the Institute will once again start the Congress programme on the Sunday (13.00, 22 September) with four key lecture programmes: Education and Training, Quality Management, Molecular Pathology and a practical microscopy workshop for cytologists.
Clinical and Laboratory Haemostasis two-day meeting: a 2019 preview

Clinical and Laboratory Haemostasis two-day meeting: a 2019 preview

The UK NEQAS for Blood Coagulation Clinical and Laboratory Haemostasis meeting will return to Sheffield Hallam University on 5-6 June. This annual scientific and scheme participants' meeting attracts speakers and delegates from across the UK and abroad; and meeting reports are a regular feature of Pathology in Practice content.
Insights into magnetic bacteria: guiding new research

Insights into magnetic bacteria: guiding new research

Researchers have long-studied magnetotactic bacteria (MTB): aquatic microbes that have the ability to orientate themselves to magnetic fields. This unusual behaviour makes them a subject of interest for improving the understanding of biomagnetism, and potentially harnessing their abilities for future technologies, such as medical nanorobots.

Upcoming Events

Lab Innovations

NEC, Birmingham (Hall 12)
30-31 October 2019

British Society for Immunology Congress

Arena and Convention Centre, Kings Dock, Liverpool Waterfront, Liverpool L3 4FP
2-5 December 2019

The genomic and molecular revolution in microbiology: in technology we trust (or do we?).

RAF Museum, Hendon, London
14 May 2020

Clinical and Laboratory Haemostasis 2020

STEM/Atrium Conference Centre, Sheffield Hallam University
3-4 June 2020

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